Little Known Facts About cees dekker.
Little Known Facts About cees dekker.
Blog Article
Applying solitary-molecule optical and AFM imaging and power-spectroscopy methods, we request to unravel the mechanistic areas of the construction and dynamics of chromosomes. Our study pursuits include things like:
It was only from the nineties nevertheless, when nanotechnology had State-of-the-art to some amount exactly where solitary molecules could possibly be manipulated, that the main experimental gadgets commenced to appear.
[Laughs] ‘It had been undoubtedly a fantastic threat! At time, I was well aware that it could go Incorrect and that I could come to be significantly less prosperous, but I just overlooked that. Curiosity has constantly been my strongest driving power. And luckily everything labored out.’
Sculpting nano-electrodes which has a transmission electron beam for electrical and geometrical characterization of nanoparticles.
To search Academia.edu and the wider Online faster and even more securely, remember to have a couple seconds to upgrade your browser.
Our investigation ranges with the biophysics of DNA to artificial cells and over and above. You should have a look under with the spectrum of our recent assignments.
All parameters were precisely the same for every panel With this online video, aside from the Original placement of the 6hb rod (shown in blue) on the nanopore. Simulations that terminated early because of translocation from the rod throughout the pore are marked by a grey background.
Dynamic ParB–DNA interactions initiate ceesdekker.net and preserve a partition condensate for bacterial chromosome segregation
In 1993, being a youthful and eager associate professor at Delft University of Know-how, I'd at first targeted the exploration endeavours of my group on measuring the electrical conductance of an individual conducting-polymer molecule. Within just two decades, we had developed a tool wherein a single wire of a phthalocyaninepolysiloxane polymer was linked amongst two intently spaced metallic nanoelectrodes.
At the moment, we also realized that it should be possible to use a single semiconducting carbon nanotube to make a transistor — and we established out to really make it. We stretched specific semiconducting nanotubes across metallic electrodes and utilized the underlying silicon substrate to be a gate electrode, creating The fundamental three-terminal layout of the discipline-result transistor (Fig.
Case in point (four) of bending configurations in 3D simulations of DNA rods on nanopores. A portion of the membrane is shown in gray, the rim on the pore is highlighted in crimson, along with a 3D rendering of your movement in the DNA rod is displayed.
Cees Dekker is Distinguished University Professor at TU Delft. Trained as being a physicist, he pioneered nanotechnology with numerous discoveries on carbon nanotubes within the 1990s. Because 2000, he moved to single-molecule biophysics and nanobiology. His existing study focuses on (i) nanopores for protein sequencing; (ii) chromosome structure, especially SMC motor protein; and (iii) developing a residing synthetic cell from lifeless molecules. Dekker is an elected member of your KNAW and fellow to your APS and the IOP.
2008, first observation of protein-coated DNA translocation through nanopores; fixed the origin of your electrophoretic drive on DNA in nanopores; found out a big velocity raise of microtubules in electrical fields; uncovered an anomalous electro-hydrodynamic orientation of microtubules; and settled the origin of noise in carbon nanotubes in liquid
2013, managed shaping of live bacterial cells into arbitrary designs; and discovery of spontaneous fluctuations within the handedness of histone tetrasomes